| Name | Perillyl alcohol | ||
| PubChem CID | 10819 | ||
| Molecular Weight | 152.23g/mol | ||
| Synonyms |
(-)-p-mentha-1,8-dien-7-ol, (S)-perillyl alcohol, 1-cyclohexene-1-methanol, 4-(1-methylethenyl)-, (4S)-, 4-isopropenyl-cyclohex-1-ene-1-methanol, cyclohex-1-ene-1-methanol, 4(1-methylethenyl), dihydrocuminyl alcohol, NEO100, NSC 641066, p-mentha-1,8-dien-7-ol, perilla alcohol, perilla alcohol, (R)-isomer, perilla alcohol, (S)-isomer, perillyl alcohol |
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| Formula | C₁₀H₁₆O | ||
| SMILES | CC(=C)C1CCC(=CC1)CO | ||
| InChI | 1S/C10H16O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,10-11H,1,4-7H2,2H3 | ||
| InChIKey | NDTYTMIUWGWIMO-UHFFFAOYSA-N | ||
| CAS Number | 536-59-4 | ||
| ChEMBL ID | CHEMBL444711 | ||
| ChEBI ID | CHEBI:15420 | ||
| Drug Bank ID | DB15289 | ||
| KEGG ID | C02452 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | GuangHuoXiang | ||
| Use Part | Aerial Parts | ||
| Habitat | GuangDong, HaiNan | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen, Stomach, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Pogostemon
-->Species: Pogostemon cablin
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| Chineses Pinyin | ZiSuGeng | ||
| Use Part | Stem | ||
| Habitat | HuBei, JiangSu, HeNan, SiChuan, GuangXi, ShanDong, GuangDong, ZheJiang, HeBei, ShanXi | ||
| Flavor | Pungent | ||
| Meridian Tropism | Lung, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Perilla
-->Species: Perilla frutescens
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| Chineses Pinyin | JiuLiXiang | ||
| Use Part | Leaf, Branchlet | ||
| Habitat | TaiWan, FuJian, GuangDong, HaiNan, GuangXi | ||
| Flavor | Pungent, Mildly bitter | ||
| Meridian Tropism | Liver, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Rutaceae
-->Genus: Murraya
-->Species: Murraya exotica
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| Chineses Pinyin | BaiSu | ||
| Habitat | JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing | ||
| Flavor | Pungent | ||
| Meridian Tropism | Lung, Large intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Perilla
-->Species: Perilla frutescens
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| Chineses Pinyin | HuiHuiSuGeng | ||
| Use Part | Stem | ||
| Habitat | JiangSu, HeNan, ZheJiang | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen, Stomach, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Perilla
-->Species: Perilla frutescens
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| Chineses Pinyin | JiuLiXiangGen | ||
| Use Part | Root | ||
| Habitat | FuJian, GuangDong, GuangXi, YunNan, HuNan, HaiNan, GuiZhou, TaiWan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Heart, Liver, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Rutaceae
-->Genus: Murraya
-->Species: Murraya exotica
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| Chineses Pinyin | ZiSu | ||
| Use Part | Seed | ||
| Habitat | Bhutan North , India , Indonesia , Japan , North Korea | ||
| Flavor | Pungent | ||
| Meridian Tropism | Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Perilla
-->Species: Perilla frutescens
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| Pair Name | Perillyl alcohol, Temozolomide | |||
| Partner Name | Temozolomide | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| In Vitro Model | HL-60 | Adult acute myeloid leukemia | Homo sapiens (Human) | CVCL_0002 |
| U-937 | Adult acute monocytic leukemia | Homo sapiens (Human) | CVCL_0007 | |
| In Vivo Model | For U937 cell implantation, used NSG-SGM3 mice and intravenously (via tail vein) injected 5×10⁴ tumor cells in a volume of 200 µL 0.9% NaCl. For 4D9 and 6D10 cells, used NOD-SCID mice. | |||
| Result | Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia | |||
